Vasculitis & polymyalgia rheumatica
Patient-reported outcomes and disease activity in giant cell arteritis: a longitudinal registry-based study
Authors' conclusion
Our study demonstrates a consistent association between PROs and disease activity in GCA, most pronounced for the physical component of HRQoL, pain and global assessment.
Study context
- Population
- GCA patients registered in NorVas up to 12 December 2024, fulfilling ACR 1990 criteria, with two patient-reported outcomes (PROs) recorded at least once, included at diagnosis1,003 observations
- Participants
- 256 patients
- Exposure
- Active vs inactive disease
- Outcome
- Association between PROs (RAND-12 PCS and MCS; VAS pain, fatigue, global disease assessment) and disease activity
Methodological detailsregistry-based, longitudinal, linear mixed effects models
- Registry-based
- Longitudinal
- Linear mixed effects models
Main finding
As reported in the abstract
during follow-up
RAND-12-PCS difference retained during follow-up
11.19
95% CI 5.67, 16.71
Pain difference retained during follow-up
−12.64
95% CI −18.58, −6.70
Global assessment difference retained during follow-up
−9.92
95% CI −15.48, −4.35
Observational data: associations, not effects.
Original publication
Patient-reported outcomes and disease activity in giant cell arteritis: a longitudinal registry-based study. Rheumatology (Oxford). Published 5 May 2026. doi:10.
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