Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review
Authors' conclusion
This analysis provides an initial step in the identification of patient-level factors for potential development of a risk algorithm to identify patients with RA who may be candidates for screening for ILD.
Study context
- Population
- Publications reporting patient-level factors, assessed before Interstitial lung disease (ILD) development, in patients with rheumatoid arthritis (RA) with and without ILD
- Comparison
- Patients with RA with vs without ILD
- Outcome
- Patient-level factors predictive of development of ILD in RA
Methodological detailsPubMed, Embase and Scopus, 10-year period up to July 2021
- PubMed, Embase and Scopus
- 10-year period up to July 2021
Pooled result
As reported in the abstract
Patient-level factors associated with development of ILD
- Consistent associations of age, sex, smoking status and autoantibodies with development of ILD
- Biomarkers such as Krebs von den Lungen 6 (diagnostic for ILD): no publications meeting criteria
- MUC5B genetic variation and MTX treatment not included in the assessment of evidence
Original publication
Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review. RMD Open. Published 28 July 2023. doi:10.
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