Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies – A longitudinal study
Authors' conclusion
Increased levels of systemic inflammation are associated with poorer PGA in patients with IIM.
Study context
- Population
- Patients with idiopathic inflammatory myopathies (IIM) in the International MyoNet registry
- Participants
- 1,200 patients
- Outcome
- Association between PGA and systemic inflammatory markers (ESR, CRP, creatine kinase (CK)) over time
- Follow-up
- Five years
Methodological detailsprospective data collection, mixed models, mediation analysis
- Prospective data collection
- Mixed models
- Mediation analysis
Main finding
As reported in the abstract
Association between inflammatory markers and PGA
- High levels of inflammatory markers were associated with worse patient global assessment (PGA) in both men and women across time points during five years
- In men, but not in women, the association between elevated erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and poorer PGA was explained by measures of function and disease activity
Observational data: associations, not effects.
Further findings
Change in PGA and inflammatory markers · first year
- PGA improved and inflammatory markers decreased
- With a few exceptions, association between improved PGA and reduced inflammatory markers partially mediated by improvements in all measures of function and disease activity
Original publication
Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies – A longitudinal study. Semin Arthritis Rheum. Published 14 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →