Fibromyalgia & musculoskeletal pain
Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia
Authors' conclusion
Morbid soreness symptoms were prevalent in FM, with the presentation and therapeutic responses different from FM pain conditions. Oxidative stress rather than lactate accumulation involved phenotype modulation of the morbid soreness in FM.
Study context
- Population
- Patients with newly diagnosed fibromyalgia (FM), prospectively recruited
- Exposure
- Newly diagnosed FM vs healthy controls; FM with mixed pain and soreness (FM-PS) vs pain dominant
- FMn = 51
- Healthy controlsn = 41reference
- Outcome
- Prevalence of soreness symptoms in FM
Methodological detailsmetabolomics profiling, healthy controls
- Metabolomics profiling
- Healthy controls
Main finding
As reported in the abstract
FM
92.2%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Malondialdehyde level, FM vs controlsHigher in FM | P = 0.009 |
Therapeutic response to conventional treatment
- Conventional treatment did not ameliorate soreness severity despite efficacy on pain
- In FM-PS, conventional treatment did not improve general disease severity despite salient efficacy on pain relief
Lactate levels
- Significantly lower in FM than controls, especially in FM-PS
Malondialdehyde level in FM-PS
- FM-PS exclusively featured increased malondialdehyde level
- P = 0.008
- Correlative trend between malondialdehyde and soreness intensity in FM-PS
- r=0.337, p=0.086
Original publication
Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia. RMD Open. Published 14 March 2023. doi:10.
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