Osteoporosis screening in the mammography setting via digital wrist tomosynthesis
Authors' conclusion
DWT can be readily implemented in mammography settings with similar diagnostic accuracy to DXA, has the potential to increase adherence to osteoporosis screening recommendations, and offers a convenient means to measure bone density within the highly accessible breast screening environment.
Study context
- Population
- Women undergoing digital wrist tomosynthesis (DWT) with a 3D mammography system and standard DXA
- Participants
- 150 women
- Comparison
- DWT bone mineral density (BMD) vs DXA BMD
- Outcome
- DWT BMD: correlation with DXA ultradistal radius BMD and diagnosis of osteoporosis and osteopenia by ultradistal T-score
Methodological detailsin vivo
- In vivo
Performance
As reported in the abstract
| Test or model | R2 with DXA ultradistal radius BMD | AUC osteoporosis (ultradistal T-score) | AUC osteopenia (ultradistal T-score) | In vivo precision errors |
|---|---|---|---|---|
| DWT | up to 0.814 | up to 0.978 | up to 0.938 | 0.91-2.3% |
DWT
R2 with DXA ultradistal radius BMDup to 0.814
AUC osteoporosis (ultradistal T-score)up to 0.978
AUC osteopenia (ultradistal T-score)up to 0.938
In vivo precision errors0.91-2.3%
Further findings
Up to
| Outcome | DWT |
|---|---|
| Diagnosis of osteopenia and osteoporosis determined by hip and spine DXA | |
| AUC osteopenia (3D DWT BMD) | 0.916 |
| AUC osteoporosis (3D DWT BMD) | 0.946 |
Diagnosis of osteopenia and osteoporosis determined by hip and spine DXA
- 3D DWT BMD performed comparably to forearm DXA BMD
Original publication
Osteoporosis screening in the mammography setting via digital wrist tomosynthesis. Osteoporos Int. Published 9 May 2025. doi:10.
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