Osteoporosis and Fracture Risk Following Benign Hysterectomy Among Female Patients in Korea
Authors' conclusion
Hysterectomy without an adnexal surgical procedure was associated with an increased osteoporosis risk within 7 years, but not afterwards, compared with the nonhysterectomy group. Hysterectomy was not associated with vertebral and hip fractures.
Study context
- Population
- Female patients aged 40 to 59 years with benign hysterectomy between 2003 and 2011, Korean National Health Insurance Data; median (IQR) age 47 (44–50) yearsmedian follow-up 10.9 years
- Participants
- 25,910 patients
- Exposure
- Benign hysterectomy with or without adnexal surgical procedure vs no hysterectomy
- Outcome
- Risk of osteoporosis
Methodological details1:1 propensity score matched, stratified-extended Cox proportional hazard model, nationwide claims data, Followed until December 31, 2020
- 1:1 propensity score matched
- Stratified-extended Cox proportional hazard model
- Nationwide claims data
- Followed until December 31, 2020
Main finding
As reported in the abstract
Osteoporosis risk · within 7 years and after 7 years
Hazard ratio (95% CI)
Hysterectomy without adnexal surgeryvs Nonhysterectomywithin 7 years
1.28(1.19–1.37)
Hysterectomy without adnexal surgeryvs Nonhysterectomyafter 7 years
0.99(0.93–1.06)
Hysterectomy with adnexal surgeryvs Nonhysterectomywithin 7 years
1.56(1.33–1.82)
Hysterectomy with adnexal surgeryvs Nonhysterectomyafter 7 years
1.20(1.04–1.40)
Observational data: associations, not effects.
Secondary outcomes
- Hysterectomy without adnexal surgery: risks of vertebral, hip and total fracture similar to nonhysterectomy
- Hysterectomy with adnexal surgery: similar trends
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Osteoporosis and Fracture Risk Following Benign Hysterectomy Among Female Patients in Korea. JAMA Netw Open. Published 1 December 2023. doi:10.
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