Opportunistic screening for osteoporosis and vertebral fracture using CT attenuation from 18F-fluorocholine positron emission tomography (PET)/CT in patients with prostate cancer
Authors' conclusion
FCh-PET/CT provides a feasible, readily available approach for opportunistic osteoporosis and fracture risk screening in men with PCa
Study context
- Population
- Men with prostate cancer who underwent both FCh-PET/CT and stand-alone CT within 6 months
- Participants
- 81 men
- Exposure
- Trabecular attenuation from low-dose CT of FCh-PET/CT vs stand-alone diagnostic CT
- Outcome
- ICC and Bland-Altman agreement between TA values from FCh-PET/CT and stand-alone CT
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Agreement of TA, FCh-PET/CT vs stand-alone CT (ICC)
- Intraclass correlation coefficients (ICC) L1
- 0.72
- ICC L2
- 0.70
- ICC L3
- 0.67
- P (L1-L3)
- p<0.001
Observational data: associations, not effects.
Secondary outcomes
Mean FCh-PET/CT trabecular attenuation (TA) by vertebral level
- L1
- 121 Hounsfield units (HU)
- L2
- 122 HU
- L3
- 118 HU
Correlation of lower attenuation with longer androgen deprivation therapy (ADT) duration
- R
- −0.43
- P
- P = 0.008
Vertebral fractures
- Patients with vertebral fractures
- 18.5%
- TA with vs without fracture (lower TA with fracture)
- 87.8 vs 127.5 HU
- P
- P = 0.01
Original publication
Opportunistic screening for osteoporosis and vertebral fracture using CT attenuation from 18F-fluorocholine PET/CT in patients with prostate cancer. RMD Open. Published 21 December 2025. doi:10.
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