Occurrence and relative risks for non-vertebral fractures in patients with ankylosing spondylitis compared with the general population: a register-based study from Sweden
Authors' conclusion
Both men and women with AS have a slightly higher risk of non-vertebral fractures than the general population. A statistically significantly higher risk of fractures of the proximal humerus, distal forearm or hip was found in men with AS in comparison to general population, where the relative risk was especially pronounced for hip fracture.
Study context
- Population
- Patients with ankylosing spondylitis (AS) and matched general population controls, Sweden, follow-up 2007–2016
- Participants
- 11,611 vs 58,050
- Exposure
- AS vs matched general population controls
- ASn = 11,611
- Controlsn = 58,050reference
- Outcome
- Non-vertebral fracture incidence (IR per 1000 person-years) and IRR, adjusted for prior fracture
Methodological detailsnationwide, register-based, matched general population controls, Poisson regression
- Nationwide
- Register-based
- Matched general population controls
- Poisson regression
Main finding
As reported in the abstract
Non-vertebral fracture, IR per 1000 person-years (men/women)
AS vs ControlsIncidence rate ratio (95% CI)
Men
1.2(1.1–1.3)
Women
1.2(1.1–1.4)
Observational data: associations, not effects.
Further findings
| Outcome | AS | Controls | IRR (95% CI) | |
|---|---|---|---|---|
| Fracture of humerus, forearm or hip, IR per 1000 person-years (men/women)Men · per_group value/spread are men; women in measures | 4.0 (95% CI 3.5–4.6) per 1000 person-years | 2.7 (95% CI 2.5–2.9) per 1000 person-years | 1.5 (1.3–1.7) | |
| IR women | 6.3 (95% CI 5.4 to 7.3) | 5.5 (95% CI 5.1 to 6.0) | ||
| Fracture of humerus, forearm or hip, IR per 1000 person-years (men/women)Women · per_group value/spread are men; women in measures | 1.1 (0.9–1.3) | |||
| Forearm fractureMen | 1.4 (1.1–1.7) | |||
| Forearm fractureWomen | 1.1 (0.9–1.4) | |||
| Hip fractureMen | 1.8 (1.4–2.3) | |||
| Hip fractureWomen | 1.0 (0.6–1.4) | |||
| Humerus fractureMen | 1.4 (0.99–1.9) | |||
| Humerus fractureWomen | 1.1 (0.8–1.6) | |||
| 0.512Incidence rate ratio (log scale) |
Original publication
Occurrence and relative risks for non-vertebral fractures in patients with ankylosing spondylitis compared with the general population: a register-based study from Sweden. RMD Open. Published 14 February 2023. doi:10.
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