Spondyloarthritis & psoriatic arthritis

New bone formation at the sacroiliac joint in axial spondyloarthritis: characterization of backfill in MRI and CT

Rheumatology (Oxford)Published Imaging study (MRI and CT) in patients with axial SpA (axSpA) from two prospective studies

Authors' conclusion

All joint space lesions show increased density and might contain calcified matrix, suggesting new bone formation, with a gradual increase in the proportion of calcified matrix towards type C lesions (backfill).

Study context

Population
Patients with axSpA who underwent both CT and MRI of the SI joints in two prospective studies97 patients with axSpA
Comparison
MRI joint space lesion types A, B and C vs cartilage, spongious bone and cortical bone on CT (Hounsfield units (HU))
  • Type An = 48
  • Type Bn = 88
  • Type Cn = 84
Outcome
CT density (HU) of MRI SI joint space lesions and surrounding cartilage and bone
Methodological detailsimage fusion, three readers
  • Image fusion
  • Three readers

Main finding

As reported in the abstract

P = 0.93

Lesion HU values significantly higher than cartilage and spongious bone, but lower than cortical bone
P < 0.001
Type C lesions denser than type A and B lesions
P < 0.001

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

New bone formation at the sacroiliac joint in axial spondyloarthritis: characterization of backfill in MRI and CT. Rheumatology (Oxford). Published 5 April 2023. doi:10.1093/rheumatology/kead142

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