Autoinflammatory & rare systemic diseases
The needed daily dose of colchicine in patients with Familial Mediterranean Fever may be higher in women: a study on behalf of the JIR cohort
Authors' conclusion
This is the first study to examine the question of colchicine dosage in relation to weight of FMF adult patients and to highlight a possible link with female gender.
Study context
- Population
- Prospectively followed homozygous Familial Mediterranean Fever (FMF) patients, French National Reference Centre, 2016–2023
- Participants
- 272 participants
- Outcome
- Daily colchicine dose
Methodological detailsretrospective evaluation of prospectively followed patients, single national reference centre
- Retrospective evaluation of prospectively followed patients
- Single national reference centre
Main finding
As reported in the abstract
- Colchicine taken
- 96%
- Female sex correlated with higher daily colchicine dose
- p = 0.0208
- Weight not associated with colchicine dose
- p = 0.4073
Observational data: associations, not effects.
Further findings
Subgroup receiving 2.5 mg/day colchicine (n = 30)
- Women (mostly women)
- n = 23; 76.7%; p = 0.018
- Lower mean weight
- P = 0.019
- Weighed < 50 kg
- 26/30 (87%)
Safety
Toxicity with 2.5 mg/day colchicine
- No toxicity noted, including patients weighing < 50 kg
Original publication
The needed daily dose of colchicine in patients with Familial Mediterranean Fever may be higher in women: a study on behalf of the JIR cohort. Arthritis Res Ther. Published 19 March 2025. doi:10.
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