Vasculitis & polymyalgia rheumatica

MRI of shoulder girdle in polymyalgia rheumatica: inflammatory findings and their diagnostic value

RMD OpenPublished Retrospective diagnostic accuracy study

Authors' conclusion

Contrast-enhanced MRI of the shoulder girdle is a reliable imaging tool with significant diagnostic value in the assessment of patients suffering from PMR and differentiation to other conditions for shoulder girdle pain.

Study context

Population
Patients with shoulder girdle pain undergoing contrast-enhanced MRI of the shoulder girdle
Participants
496 MRI scans
Comparison
Polymyalgia rheumatica (PMR) vs non-PMR causes of shoulder girdle pain
  • PMRn = 122
  • Non-PMRn = 374reference
Outcome
Number of inflamed sites out of six predefined non-synovial sites and three synovial sites, and ability to differentiate PMR from non-PMR
Methodological detailsblinded image assessment by two radiologists, contrast-enhanced MRI
  • Blinded image assessment by two radiologists
  • Contrast-enhanced MRI

Performance

As reported in the abstract

Number of inflamed non-synovial sites (of six)

PMR

3.4

mean · SD 1.7

Non-PMR

1.1

mean · SD 1.4

P < 0.001

Further findings

Mean

OutcomePMRNon-PMR
Number of synovial sites with synovitis (of three)2.5 (SD 0.8)1.9 (SD 1.1)
  • Diagnostic performance for PMR vs non-PMR: Inflammation at 3 of 6 non-synovial sites sensitivity 73.8% · specificity 85.8%
  • Diagnostic performance for PMR vs non-PMR: Synovitis alone sensitivity 86.1% · specificity 36.1%

Number of synovial sites with synovitis (of three)

Differed significantly, but with inferior discriminatory effect

Diagnostic performance for PMR vs non-PMR

Non-synovial criterion had overall better performance than synovitis alone

Original publication

MRI of shoulder girdle in polymyalgia rheumatica: inflammatory findings and their diagnostic value. RMD Open. Published 9 May 2024. doi:10.1136/rmdopen-2024-004169

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