The association of microvascular disease and endothelial dysfunction with vertebral trabecular bone mineral density : The MESA study
Authors' conclusion
We conclude that there is little evidence to connect thoracic spine trabecular BMD to microvascular disorders or to endothelial dysfunction among multi-ethnic middle-aged and older adults.
Study context
- Population
- Multi-ethnic middle-aged and older adults in the Multi-Ethnic Study of Atherosclerosis (MESA)MESA
- Participants
- 6,814 participants
- Outcome
- Association of thoracic vertebral trabecular BMD (from chest CT) with markers of microvascular disease (UACR, retinal arteriolar and venular widths) and endothelial dysfunction (brachial FMD; ICAM-1, VCAM-1, L-selectin, P-selectin, E-selectin)
Methodological detailslinear regression
- Linear regression
Main finding
As reported in the abstract
- No significant associations of urine albumin to creatinine ratios (UACR), retinal arteriolar or venular widths, or flow mediated dilation (FMD) with bone mineral density (BMD)
- No statistically significant association of spine trabecular BMD with levels of endothelial adhesion markers
Observational data: associations, not effects.
Further findings
Results by sex
- Men and women had largely similar results
Original publication
The association of microvascular disease and endothelial dysfunction with vertebral trabecular bone mineral density : The MESA study. Osteoporos Int. Published 24 June 2024. doi:10.
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