Magnetic resonance imaging patterns revealing muscle pathology and clinical features in idiopathic inflammatory myopathies
Authors' conclusion
Muscle MRI holds promise in predicting muscle pathology, disease subtypes and clinical manifestations of IIMs.
Study context
- Population
- New-onset IIM patients undergoing proximal upper and/or lower limb muscle magnetic resonance imaging (MRI)56 underwent muscle biopsy
- Participants
- 85 patients
- Outcome
- Association of muscle MRI oedema patterns with muscle pathology (inflammatory cell infiltration sites on biopsy) and clinical features
Methodological detailsunivariate and multivariate analyses
- Univariate and multivariate analyses
Main finding
As reported in the abstract
Foggy pattern and endomysial infiltration, OR
11.9
P = 0.005
Honeycomb pattern and perimysial infiltration, OR
6.0
P = 0.014
Fascial pattern and fascial infiltration, OR
16.9
P < 0.001
Observational data: associations, not effects.
Further findings
MRI patterns by disease subtype
- Honeycomb pattern characteristic of anti-TIF1γ or anti-Mi2 antibodies and MSA-negative DM
- Foggy pattern characteristic of anti-SRP or anti-HMGCR antibodies and MSA-negative polymyositis (PM)
MRI patterns and clinical characteristics
- Honeycomb pattern and malignancy, OR
- 6.87 (P < 0.001)
- Honeycomb pattern and Gottron sign, OR
- 8.05 (P = 0.002)
- Foggy pattern and muscle weakness, OR
- 11.24 (P = 0.005)
- Dense dot pattern and dysphagia, OR
- 6.27 (P = 0.006)
- Dense dot pattern and malignancy, OR
- 8.49 (P = 0.002)
Original publication
Magnetic resonance imaging patterns revealing muscle pathology and clinical features in idiopathic inflammatory myopathies. Rheumatology (Oxford). Published 26 February 2024. doi:10.
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