Spondyloarthritis & psoriatic arthritis
Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort
Authors' conclusion
The current analysis revealed the occurrence of additional inflammatory and post-inflammatory changes suggestive of axial PsA (axPsA) and a trend for better clinical outcomes for patients treated with secukinumab.
Study context
- Population
- PsA patients with axial manifestations from the MAXIMISE trial
Methodological detailsre-read of baseline spinal MRIs, logistic regression modelling
- Re-read of baseline spinal MRIs
- Logistic regression modelling
Primary result
As reported in the abstract
Baseline MRI findings (proportion of patients)
- Spinal process inflammation
- 11.1%
- Post-inflammatory changes (FAt Spondyloarthritis Spine Score)
- 20.2%
- At least one type of degenerative change
- 64%
- Pfirrmann grade ≥3 (most common degenerative change)
- 51.1%
- Inflammatory or post-inflammatory changes (primary and re-read MRI combined)
- 67.1%
- Degenerative changes alone
- 21.2%
Further findings
Differential treatment effect by imaging features (ASAS20, ASAS40, BASDAI50 responses)
- Post-inflammatory changes associated with a trend for better efficacy outcomes, not statistically significant
- Trend for worse outcomes in the presence of degenerative changes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort. Rheumatology (Oxford). Published 24 April 2023. doi:10.
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