Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation
Authors' conclusion
H&E-stained images of TKR explant synovium can be correctly classified as OA or RA in 82% of samples.
Study context
- Population
- Osteoarthritis (OA) and rheumatoid arthritis (RA) patients; H&E-stained synovial tissue samples from total knee replacement explants147 OA and 60 RA patients
- Comparison
- Pathologist-scored histology features and/or computer vision cell density to discriminate OA from RA synovium
- Outcome
- Discrimination between OA and RA synovium (micro-AUC)
Methodological detailsrandom forest model, computer vision-quantified cell density
- Random forest model
- Computer vision-quantified cell density
Performance
As reported in the abstract
Discrimination of OA vs RA, micro-AUC
| Test or model | micro-AUC | Optimal threshold | Sensitivity | Specificity |
|---|---|---|---|---|
| Pathologist scores | 0.85±0.06 | |||
| Cell density | 0.87±0.04 | 3400 cells/mm² | 0.82 | 0.82 |
| Pathologist scores + cell density | 0.92±0.06 |
micro-AUC
Pathologist scores0.85±0.06
Cell density0.87±0.04
Pathologist scores + cell density0.92±0.06
Optimal threshold
Pathologist scores— not stated in the abstract
Cell density3400 cells/mm²
Pathologist scores + cell density— not stated in the abstract
Sensitivity
Pathologist scores— not stated in the abstract
Cell density0.82
Pathologist scores + cell density— not stated in the abstract
Specificity
Pathologist scores— not stated in the abstract
Cell density0.82
Pathologist scores + cell density— not stated in the abstract
Further findings
Histology features, OA vs RA synovium
- OA: increased mast cells and fibrosis
- P < 0.001
- RA: increased lymphocytic inflammation, lining hyperplasia, neutrophils, detritus, plasma cells, binucleate plasma cells, sub-lining giant cells, fibrin
- all p < 0.001
- RA: increased Russell bodies
- P = 0.019
- RA: increased synovial lining giant cells
- P = 0.003
Original publication
Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation. Arthritis Res Ther. Published 2 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →