Lupus nephritis and U1-RNP-antibodies are associated with low bone mineral density and osteoporosis in patients with systemic lupus erythematosus: baseline findings in a sub-cohort of patients with inflammatory rheumatic diseases
Authors' conclusion
Disease severity indicated by LN, high CRP, presence of U1-RNP antibodies, and extended disease duration are detrimental to bone health.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) with current or past GC treatment, fulfilling the EULAR/ACR 2019 SLE classification criteria
- Participants
- 110 patients
- Outcome
- Disease-specific factors associated with BMD and the risk of osteoporosis
- Follow-up
- Baseline
Methodological detailsbaseline data of a consecutive subcohort, multivariable linear and logistic regression
- Baseline data of a consecutive subcohort
- Multivariable linear and logistic regression
Main finding
As reported in the abstract
Osteoporosis prevalence
41%
Observational data: associations, not effects.
Further findings
Lupus nephritis · baseline
- Lupus nephritis (LN) present
- 35%
- LN predominantly classes IV and V
- 61% (23/38)
Discrimination of past vertebral fractures by 3D-DXA femur parameters
- 3D bone structure analysis may be helpful in discriminating past vertebral fractures
Original publication
Lupus nephritis and U1-RNP-antibodies are associated with low bone mineral density and osteoporosis in patients with systemic lupus erythematosus: baseline findings in a sub-cohort of patients with inflammatory rheumatic diseases. Arthritis Res Ther. Published 28 July 2025. doi:10.
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