Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years
Authors' conclusion
Vitamin D supplementation over 2 years or maintaining vitamin D sufficiency for 5 years was not associated with statistically significant differences in change in knee symptom scores over 5 years.
Study context
- Population
- Participants with knee osteoarthritis (OA) from the Hobart centre of the VIDEO trial
- Participants
- 173 participants
- Comparison
- Vitamin D supplementation vs placebo; maintaining sufficient vs not maintaining sufficient vitamin D over 5 years
- Maintaining sufficient vitamin Dn = 79
- Not maintaining sufficient vitamin Dn = 61reference
- Primary endpoint
- Change in knee symptoms
- Follow-up
- 5 years
Methodological detailssingle-centre (Hobart centre), 3-year post-trial follow-up after 2-year treatment
- Single-centre (Hobart centre)
- 3-year post-trial follow-up after 2-year treatment
Primary result
As reported in the abstract
Change in knee symptoms, depression, serum IL6 and hs-CRP · 3 years after trial cessation
- No significant difference in either comparison
Further findings
| Outcome | β (95% CI) |
|---|---|
| WOMAC function, participants with no knee surgery (subgroup)Vitamin D vs Placebo | - 83.7 (- 167.3, 0) |
| Depression scores, participants with no knee surgery (subgroup)Vitamin D vs Placebo | - 1.3 (- 2.3, - 0.2) |
| WOMAC knee pain · 5 yearsMaintaining sufficient vitamin D vs Not maintaining sufficient vitamin D | - 33.9 (- 65.7, - 2) |
| WOMAC physical dysfunction · 5 yearsMaintaining sufficient vitamin D vs Not maintaining sufficient vitamin D | - 105.5 (- 198.2, - 12.8) |
Original publication
Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years. Arthritis Res Ther. Published 23 September 2023. doi:10.
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