Is T-cell senescence associated with inflammatory arthritis and disease burden? A systematic review
Authors' conclusion
Our findings indicate that the level of senescent T-cells (T-helper CD4 cells and cytotoxic CD8 T-cells) is higher in patients when compared to healthy populations, and with their altered characteristics, these senescent cells could mechanistically contribute to disease progression, hence symptom burden.
Study context
- Population
- Patients with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA)20 studies
- Comparison
- Patients with RA, axSpA or PsA vs healthy populations
- Outcome
- Whether levels of senescent T-cells are correlated with disease burden
Methodological details20 studies included out of 3203 identified by the search
- 20 studies included out of 3203 identified by the search
Pooled result
As reported in the abstract
Level of senescent T-cells (CD4 T-helper and CD8 cytotoxic T-cells)
- Higher in patients than in healthy populations
Original publication
Is T-cell senescence associated with inflammatory arthritis and disease burden? A systematic review. Semin Arthritis Rheum. Published 14 May 2025. doi:10.
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