Autoinflammatory & rare systemic diseases
Increased prevalence of malignancies in patients with IgG4-related disease: implications for clinical care
Main finding · Cancer before or after IgG4-RD diagnosisResult — go to the resultStandardized incidence ratio 2.54Authors' conclusion
The prevalence of cancer in patients with IgG4-RD is increased compared with the Italian population and mechanistically suggests a possible paraneoplastic association.
Study context
- Population
- Patients with IgG4-related disease (IgG4-RD) (Italy)
- Participants
- 210 patients
- Exposure
- IgG4-RD vs Italian general population
- IgG4-RDn = 210
- Outcome
- Prevalence of malignancies in IgG4-RD
Methodological detailscomparison with general population registry (WHO Global Cancer Observatory), standardised incidence ratio
- Comparison with general population registry (WHO Global Cancer Observatory)
- Standardised incidence ratio
Main finding
Cancer before or after IgG4-RD diagnosis
Standardized incidence ratio
2.54
P = 0.007
Events by group
IgG4-RD
18%
37 of 210
As reported in the abstract
Observational data: associations, not effects.
Further findings
Malignancy Standardized Incidence Ratio (SIR) vs general Italian population, by sex (subgroup)
| SIR | P value | |
|---|---|---|
| Males | 2.78 | P = 0.005 |
| Females | 1.15 | P > 0.05 |
Cancer by IgG4-RD phenotype
- Solid and haematologic tumours more frequent in pancreato-biliary IgG4-RD
Timing of malignancy relative to IgG4-RD diagnosis
- Malignancies diagnosed before IgG4-RD
- 32
- Malignancies diagnosed after IgG4-RD
- 16
- Interval from IgG4-RD to cancer shorter than from cancer to IgG4-RD
- Most tumours after IgG4-RD developed within 36 months of IgG4-RD diagnosis
Original publication
Increased prevalence of malignancies in patients with IgG4-related disease: implications for clinical care. Rheumatology (Oxford). Published 2 May 2024. doi:10.
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