Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry
Authors' conclusion
Risk factors for severe COVID-19 outcomes were similar throughout pandemic epochs in unvaccinated people with RDs.
Study context
- Population
- Unvaccinated patients with rheumatic diseases and COVID-19 in the COVID-19 Global Rheumatology Alliance Registry, March 2020–June 2022
- Participants
- 19,256 patients
- Exposure
- Risk factors for severe COVID-19 across pandemic epochs
- Outcome
- Severe COVID-19 (main analysis: risk factors across pandemic epochs in all unvaccinated patients; ordinal outcome: not hospitalized, hospitalized, death)
Methodological detailsordinal logistic regression (not hospitalized, hospitalized, death), stratified by pandemic epoch, subanalyses by RD type
- Ordinal logistic regression (not hospitalized, hospitalized, death)
- Stratified by pandemic epoch
- Subanalyses by RD type
Main finding
As reported in the abstract
Risk factors for worse COVID-19 outcomes across epochs
- Older age, male sex, more comorbidities, GC use, higher disease activity and lower human development index (HDI) regions associated with worse outcomes across epochs
Observational data: associations, not effects.
Further findings
RA subgroup
- SSZ and B-cell-depleting therapy associated with worse outcomes
- TNFi associated with improved outcomes
Connective tissue disease or vasculitis subgroup
- B-cell-depleting therapy associated with worse outcomes
Original publication
Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry. Arthritis Care Res (Hoboken). Published 7 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →