Identifying the strongest novel gene-respiratory disease interactions for rheumatoid arthritis risk
An erratum to this article was published (Semin Arthritis Rheum, 24 Oct 2026 ↗)
Authors' conclusion
This study identified novel respiratory risk factors and gene-respiratory endotypes for RA
Study context
- Population
- Mayo Clinic and Mass General Brigham biobanks (mean age 64 years, 70% female in Mayo Clinic (MC); 54 years, 76% female in Mass General Brigham (MGB))
- Participants
- 1,125 vs 4,495
- Comparison
- Gene-respiratory exposure interactions for incident rheumatoid arthritis (RA) risk
- RA casesn = 1,125
- Non-RA controlsn = 4,495reference
- Outcome
- Interactions between genetic (known RA risk alleles) and respiratory exposures for incident RA risk
Methodological detailsmatched on age, sex and duration of electronic health record (EHR) history, discovery (Mayo Clinic biobank) and validation (Mass General Brigham biobank), logistic regression
- Matched on age, sex and duration of EHR history
- Discovery (Mayo Clinic biobank) and validation (Mass General Brigham biobank)
- Logistic regression
Main finding
As reported in the abstract
Gene-respiratory interactions validated in MGB (four novel)
Estimate (95% CI)
CD83/RNF182 (rs12530098)-acute pharyngitis
OR (seronegative RA, MC) 4.06(1.61–10.3)
CD83/RNF182 (rs12530098)-acute pharyngitis
OR (seronegative RA, MGB) 3.68(1.42–9.56)
JARID2 (rs113532504)-asthma
OR (seropositive RA, MC) 2.66(1.30–5.44)
JARID2 (rs113532504)-asthma
OR (seropositive RA, MGB) 1.93(1.20–3.08)
Observational data: associations, not effects.
Further findings
Respiratory exposures and incident RA (MC)
| OR (95% CI) | ||
|---|---|---|
| ILD | 1.55 (1.00–2.40) | |
| Overall respiratory burden | 1.67 (1.30–2.15) | |
| 0.512Odds ratio (log scale) |
Dose-response: CD83/RNF182-acute pharyngitis interaction, highest respiratory burden
| OR (95% CI) | ||
|---|---|---|
| CD83/RNF182-acute pharyngitis, highest respiratory burdenStrongest dose-response association | 8.54 (1.59–45.9) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Identifying the strongest novel gene-respiratory disease interactions for rheumatoid arthritis risk. Semin Arthritis Rheum. Published 30 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →