Vasculitis & polymyalgia rheumatica

Identification of outcome domains in immune checkpoint inhibitor-induced inflammatory arthritis and polymyalgia rheumatica: A scoping review by the OMERACT irAE working group

Semin Arthritis RheumPublished Scoping review

Authors' conclusion

There is considerable heterogeneity in the domains used to clinically characterize ICI-induced IA and ICI-induced PMR.

Study context

Population
Publications providing clinical descriptions and domains of immune checkpoint inhibitors (ICI)-induced inflammatory arthritis and ICI-induced PMR (Medline, EMBASE, Cochrane, CINHL through March 2021)69 publications
Outcome
Clinical descriptors and outcome domains used for ICI-induced IA and ICI-induced PMR, mapped to OMERACT core areas
Methodological detailsOMERACT 2.1 Filter mapping of domains to core areas
  • OMERACT 2.1 Filter mapping of domains to core areas

Main finding

As reported in the abstract

Publications identified
69
Domains mapped to pathophysiology/manifestations core area
24
Signs/symptoms domains
13
Lab domains
6
Imaging domains
5
Publications referencing irAE treatment
43
Publications referencing subsequent response
35
Publications referencing tumor response
32

Original publication

Identification of outcome domains in immune checkpoint inhibitor-induced inflammatory arthritis and polymyalgia rheumatica: A scoping review by the OMERACT irAE working group. Semin Arthritis Rheum. Published 26 October 2022. doi:10.1016/j.semarthrit.2022.152110

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