Vasculitis & polymyalgia rheumatica
Health-related quality of life in patients with ANCA vasculitides compared to rheumatoid arthritis: a cross-sectional comparative study
Authors' conclusion
In patients with AAVs, HRQoL correlated more with organ damage and less with disease activity whereas in RA patients, it correlated with both.
Study context
- Population
- Patients with AAV and RA recruited from three tertiary rheumatology clinics
- Participants
- 66 / 71 / 1,007
- Exposure
- AAV vs RA vs healthy controls
- AAVn = 66
- RAn = 71
- Healthy controls (HC)n = 1,007reference
- Outcome
- HRQoL by Short Form 36 Health Survey (PCS and MCS)
Methodological detailsmulticentre, comparative, historical controls
- Multicentre
- Comparative
- Historical controls
Main finding
As reported in the abstract
SF-36 PCS and MCS vs HC
- Overall, RA had similar health-related quality of life (HRQoL) compared with AAV
- AAV vs HC: P < 0.05
- RA vs HC: P < 0.05
Observational data: associations, not effects.
Further findings
HRQoL within AAV by subtype, damage and activity
- Worse in MPA vs GPA (physical components)
- Worse with high (VDI ≥ 3) vs low (VDI < 3) damage scores
- Did not differ between active (BVASv3 ≥ 1) vs inactive (BVASv3 < 1) disease
HRQoL within RA
- Correlated with disease activity (DAS28-ESR) and functional impairment/damage (HAQ)
Active RA vs active AAV
- Active RA had worse HRQoL compared with active AAV
Original publication
Health-related quality of life in patients with ANCA vasculitides compared to rheumatoid arthritis: a cross-sectional comparative study. Rheumatology (Oxford). Published 12 May 2023. doi:10.
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