Glucocorticoid sparing effect of Janus kinase inhibitors compared to biologic disease modifying anti-rheumatic drugs in rheumatoid arthritis, a single-centre retrospective analysis
Main finding · GC discontinuationResult — go to the resultAdjusted odds ratio 1.63 95% CI 1.02–2.60Authors' conclusion
Our findings indicate that JAKi facilitate more rapid glucocorticoid tapering compared with bDMARDs in RA patients.
Study context
- Population
- Rheumatoid arthritis (RA) patients treated with janus kinase inhibitors (JAKi) or bDMARDs at a single centre
- Participants
- 716 patients
- Exposure
- JAKi vs bDMARDs in RA
- JAKin = 156
- bDMARDsn = 560reference
- Outcome
- GC tapering, rescue therapy and discontinuation
Methodological detailssingle-centre, mixed-effects models, Poisson regression and multivariable logistic regression, adjusted for baseline disease activity, demographic factors and treatment line
- Single-centre
- Mixed-effects models, Poisson regression and multivariable logistic regression
- Adjusted for baseline disease activity, demographic factors and treatment line
Main finding
GC discontinuation
Adjusted odds ratio
1.63
95% CI 1.02–2.60
P = 0.039
JAKivs bDMARDs
aOR 1.63 (95% CI 1.02–2.60); P = 0.039
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Rate ratio (95% CI) | |
|---|---|---|
| Need for GC rescue therapySignificantly higher in the bDMARD group | 2.66 (1.88–3.74) | |
| 0.20.5125Rate ratio (log scale) |
Original publication
Glucocorticoid sparing effect of Janus kinase inhibitors compared to biologic disease modifying anti-rheumatic drugs in rheumatoid arthritis, a single-centre retrospective analysis. Rheumatology (Oxford). Published 21 August 2024. doi:10.
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