Glucocorticoid exposure and the risk of serious infections in rheumatoid arthritis: a marginal structural model application
Authors' conclusion
Our results broadly agree with previous observational studies showing a dose dependent increased risk of infection associated with (recent) use of oral glucocorticoids.
Study context
- Population
- Newly diagnosed RA patients from the Swedish Rheumatology Quality Register, 2007–2018, followed for 3 years after the first rheumatology visit
- Participants
- 9,654 participants
- Exposure
- Oral GC dose patterns vs no GC use
- Outcome
- Incidence of serious infections (hospitalisation for infection)
- Follow-up
- 3 years
Methodological detailsmarginal structural models, pooled logistic regression, adjusted for time-varying confounders, register-based (Swedish Rheumatology Quality Register)
- Marginal structural models
- Pooled logistic regression
- Adjusted for time-varying confounders
- Register-based (Swedish Rheumatology Quality Register)
Main finding
As reported in the abstract
Serious infections
NNH
83
Low · low GC doses for the first 6 months; one additional serious infection per 83 treated
NNH
125
High · high GC doses for the first 3 months; one additional serious infection per 125 treated
Observational data: associations, not effects.
Original publication
Glucocorticoid exposure and the risk of serious infections in rheumatoid arthritis: a marginal structural model application. Rheumatology (Oxford). Published 23 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →