Global ultrasound synovitis scores reflect symptom severity and patient outcomes in chronic chikungunya disease
Authors' conclusion
Global ultrasound scores for synovitis were found to be a relevant measure to support clinical observations in studies of chronic post-chikungunya joint disease.
Study context
- Population
- Patients with acute chikungunya virus infection (mean age 34 years, 67% female)
- Participants
- 60 patients
- Outcome
- Correlation of global US synovitis and tenosynovitis scores and serum inflammatory markers with clinical symptoms and outcomes
Methodological detailsfollow-up at 3, 6 and 12 months, standardized US of 40 joints
- Follow-up at 3, 6 and 12 months
- Standardized US of 40 joints
Main finding
As reported in the abstract
Correlation of global US synovitis score with clinical measures · 3 months
- Tender joint counts, r = 0.54
- P < 0.0001
- Pain severity, r = 0.59
- P < 0.0001
- Musculoskeletal stiffness, r = 0.42
- P < 0.001
- RAPID3 scores, r = 0.59
- P < 0.0001
Observational data: associations, not effects.
Further findings
Persistent symptoms
- Persistent symptoms at 3 months
- 57%
- Persistent symptoms at 12 months
- 30%
Serum inflammatory markers vs persistent symptoms
- Serum inflammatory markers were poorly associated with persistent symptoms during follow-up
Original publication
Global ultrasound synovitis scores reflect symptom severity and patient outcomes in chronic chikungunya disease. Rheumatology (Oxford). Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →