Across rheumatic diseases

Global burden and trends of musculoskeletal disorders in postmenopausal elderly women: a 1990–2021 analysis with projections to 2045

Arthritis Res TherPublished Secondary analysis of Global Burden of Disease 2021 data

Authors' conclusion

From 1990 to 2021, the global burden of MSDs among PMW has risen significantly, with notable regional disparities

Study context

Population
Postmenopausal women (PMW), Global Burden of Disease (GBD) 2021 data, 1990–2021
Primary endpoint
Age-standardized prevalence and DALYs of RA, OA, low back pain, neck pain, gout and other musculoskeletal conditions
Follow-up
1990 to 2021
Methodological detailsBayesian Age-Period-Cohort projections to 2045, Slope Index of Inequality and Concentration Index, decomposition analysis
  • Bayesian Age-Period-Cohort projections to 2045
  • Slope Index of Inequality and Concentration Index
  • Decomposition analysis

Primary result

As reported in the abstract

Burden of MSDs in PMW, 1990–2021
Rheumatoid arthritis (RA), osteoarthritis (OA) and gout >50% of total burden in women across all age groups
more than 50%
RA burden vs premenopausal women
1.2 times higher
OA burden vs premenopausal women
3.1 times higher
Gout burden vs premenopausal women
2.9 times higher
Burden of gout in PMW
74%

Further findings

Projected burden by 2045

Global burden of musculoskeletal disorders (MSDs) could double
OA potentially affecting nearly 50% of PMW

Original publication

Global burden and trends of musculoskeletal disorders in postmenopausal elderly women: a 1990–2021 analysis with projections to 2045. Arthritis Res Ther. Published 19 June 2025. doi:10.1186/s13075-025-03587-8

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