Global burden and trends of musculoskeletal disorders in postmenopausal elderly women: a 1990–2021 analysis with projections to 2045
Authors' conclusion
From 1990 to 2021, the global burden of MSDs among PMW has risen significantly, with notable regional disparities
Study context
- Population
- Postmenopausal women (PMW), Global Burden of Disease (GBD) 2021 data, 1990–2021
- Primary endpoint
- Age-standardized prevalence and DALYs of RA, OA, low back pain, neck pain, gout and other musculoskeletal conditions
- Follow-up
- 1990 to 2021
Methodological detailsBayesian Age-Period-Cohort projections to 2045, Slope Index of Inequality and Concentration Index, decomposition analysis
- Bayesian Age-Period-Cohort projections to 2045
- Slope Index of Inequality and Concentration Index
- Decomposition analysis
Primary result
As reported in the abstract
Burden of MSDs in PMW, 1990–2021
- Rheumatoid arthritis (RA), osteoarthritis (OA) and gout >50% of total burden in women across all age groups
- more than 50%
- RA burden vs premenopausal women
- 1.2 times higher
- OA burden vs premenopausal women
- 3.1 times higher
- Gout burden vs premenopausal women
- 2.9 times higher
- Burden of gout in PMW
- 74%
Further findings
Projected burden by 2045
- Global burden of musculoskeletal disorders (MSDs) could double
- OA potentially affecting nearly 50% of PMW
Original publication
Global burden and trends of musculoskeletal disorders in postmenopausal elderly women: a 1990–2021 analysis with projections to 2045. Arthritis Res Ther. Published 19 June 2025. doi:10. 1186/ s13075-025-03587-8
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