Across rheumatic diseases

French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases

Joint Bone SpinePublished Guideline

Methodological detailsnational recommendations, two systematic literature reviews (2005-2024), multidisciplinary task force, expert consensus with multiple voting rounds, Multidisciplinary task force: rheumatologists, oncologists, pulmonologists, gynecologists and patient representatives
  • National recommendations
  • Two systematic literature reviews (2005-2024)
  • Multidisciplinary task force
  • Expert consensus with multiple voting rounds
  • Multidisciplinary task force: rheumatologists, oncologists, pulmonologists, gynecologists and patient representatives

Recommendations

As issued by the authors

  1. Apply general population cancer screening programs, adapted to immunocompromised patients with chronic inflammatory rheumatic diseases (CIRDs); may involve earlier and/or more frequent screening

  2. Systematic risk assessment before initiating therapies

  3. Reinforced preventive strategies such as HPV vaccination and smoking cessation

  4. At least one dermatologic evaluation during follow-up

  5. Decisions on higher-risk therapies, such as JAK inhibitors and abatacept, should involve multidisciplinary discussions

Original publication

French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases. Joint Bone Spine. Published 12 July 2025. doi:10.1016/j.jbspin.2025.105944

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