Fragility fractures of the pelvis and long-term outcomes among older adults with osteoporosis: a real-world cohort study
Authors' conclusion
FFPs are associated with substantially increased long-term mortality, morbidity, and healthcare utilization in older adults with osteoporosis.
Study context
- Population
- Patients aged 65 years or older with osteoporosis, TriNetX Research Networkafter matching
- Participants
- 76,556 patients
- Exposure
- FFP vs non-FFP matched controls
- FFPn = 38,278
- Non-FFPn = 38,278reference
- Outcome
- Mortality, hospital readmission and subsequent fractures
- Follow-up
- 1-, 3- and 5-year follow-up
Methodological detailsglobal, propensity score matching 1:1, TriNetX Research Network, age-stratified subgroup analyses
- Global
- Propensity score matching 1:1
- TriNetX Research Network
- Age-stratified subgroup analyses
Main finding
As reported in the abstract
5 years
Each group vs Non-FFPEstimate (95% CI)
FFP
HR (mortality) 1.59(1.54–1.64)
FFP
HR (hospital readmission) 1.98(1.93–2.03)
FFP
HR (subsequent fractures) 2.86(2.76–2.96)
Observational data: associations, not effects.
Secondary outcomes
Mortality and subsequent fractures (summary estimates)
- Mortality with fragility fractures of the pelvis, HR
- 1.63 (95% CI 1.58-1.69)
- Subsequent fractures with fragility fractures of the pelvis, HR
- 2.95
Relative fracture risk, age subgroup 75-79 years
- Markedly higher relative fracture risk among patients aged 75-79 years, HR
- 4.94
Immobility-related complications
- FFP associated with increased risks of immobility-related complications, including infections, thromboembolic events and pressure ulcers
Age-stratified subgroups
- Consistent and highly elevated relative risks across the three strata aged 65-79 years; absolute event burdens greatest among those aged 80 years or older
Original publication
Fragility fractures of the pelvis and long-term outcomes among older adults with osteoporosis: a real-world cohort study. Osteoporos Int. Published 9 May 2026. doi:10.
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