Fracture risks in patients aged 50 years and older with panhypopituitarism: a nationwide cohort study
Authors' conclusion
Patients with panhypopituitarism, particularly males, have a higher risk of fracture than matched controls.
Study context
- Population
- Patients aged ≥ 50 years with panhypopituitarism and matched controls, Korea National Health Insurance Service (NHIS) Databasematched cohort
- Exposure
- Panhypopituitarism vs matched controls
- Panhypopituitarismn = 3,877
- Outcome
- Gender- and site-specific fracture risks: MOFs, vertebral fractures (VFs), non-VFs and hip fractures (HFs)
Methodological detailsnationwide, 1:10 age-, sex- and index year-matched controls
- Nationwide
- 1:10 age-, sex- and index year-matched controls
Main finding
As reported in the abstract
Fracture risk in men (subgroup analysis by sex)
Each group vs controlsEstimate (95% CI)P value
Panhypopituitarism
HR (MOFs, men) 2.16(1.87–2.48)
all P < 0.001Panhypopituitarism
HR (VFs, men) 2.13(1.80–2.51)
all P < 0.001Panhypopituitarism
HR (non-VFs, men) 2.41(1.94–3.00)
all P < 0.001Panhypopituitarism
HR (HFs, men) 2.28(1.59–3.27)
all P < 0.001Panhypopituitarism
HR (MOFs, women) 1.29(1.16–1.42)
all P < 0.001Panhypopituitarism
HR (VFs, women) 1.45(1.29–1.63)
all P < 0.001Panhypopituitarism
HR (HFs, women) 1.68(1.26–2.24)
all P < 0.001Observational data: associations, not effects.
Further findings
Factors associated with higher major osteoporotic fractures (MOFs)
- Age, female sex, fracture history, cerebrovascular disease, dementia and low income associated with higher MOFs
Original publication
Fracture risks in patients aged 50 years and older with panhypopituitarism: a nationwide cohort study. Osteoporos Int. Published 8 July 2025. doi:10.
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