Autoinflammatory & rare systemic diseases
Evaluation of Myocarditis in Patients With Still Disease: Clinical Findings From the Multicenter International Autoinflammatory Disease Alliance (AIDA) Network Still Disease Registry
Authors' conclusion
The most common feature was the pericarditis, but a more severe clinical picture was also reported in patients with myocarditis. The latter was associated with increased mortality rate and higher systemic score, identifying patients who should be carefully managed.
Study context
- Population
- Consecutive patients with Still disease and cardiac involvement (pericarditis, tamponade, myocarditis and/or aseptic endocarditis) in the AIDA Network Still disease registry21.9% children
- Participants
- 73 patients
- Exposure
- Patients with myocarditis vs patients without myocarditis
- Outcome
- Cardiac involvement, with a focus on myocarditis, and predictive factors for myocarditis
Methodological detailsinternational, consecutive patients, AIDA Network Still disease registry
- International
- Consecutive patients
- AIDA Network Still disease registry
Main finding
As reported in the abstract
Cardiac manifestations
Pericarditis (most common)
90.4%
Myocarditis
26%
Endocarditis
2.7%
Tamponade
1.4%
Observational data: associations, not effects.
Further findings
Clinical features, myocarditis vs without
- Significantly increased frequencies of skin rash and pleuritis, and higher systemic scores, with myocarditis
- Higher mortality rate with myocarditis
Independent predictors of myocarditis (regression models)
- Skin rash and the systemic score independently predicted myocarditis
Original publication
Evaluation of Myocarditis in Patients With Still Disease: Clinical Findings From the Multicenter International AIDA Network Still Disease Registry. J Rheumatol. Published 15 November 2024. doi:10.
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