Efficacy of non-pharmacological interventions: a systematic review informing the 2023 EULAR recommendations for the management of fatigue in people with inflammatory rheumatic and musculoskeletal diseases
An erratum to this article was published (RMD Open, 14 Dec 2023 ↗)
Authors' conclusion
Physica activity or exercise and psychoeducational interventions are efficacious and safe for managing fatigue in people with I-RMDs.
Study context
- Population
- Adults with inflammatory rheumatic and musculoskeletal diseases (I-RMDs)82 RCTs
- Comparison
- Non-pharmacological interventions vs control for fatigue in I-RMDs
- Outcome
- Reduction of fatigue
Methodological detailsconducted according to the Cochrane Handbook, two independent reviewers
- Conducted according to the Cochrane Handbook
- Two independent reviewers
Pooled result
As reported in the abstract
Fatigue
SMD (95% CI)
Physical activity or exerciseRA
−0.23(−0.37 to −0.1)
Physical activity or exerciseSLE
−0.54(−1.07 to −0.01)
Physical activity or exerciseSpondyloarthritis
−0.94(−1.23 to −0.66)
Physical activity or exerciseSjögren's syndrome; not significant
−0.83(−2.13 to 0.47)
Physical activity or exerciseSSc; not significant
−0.66(−1.33 to 0.02)
Psychoeducational interventionsRA
−0.32(−0.48 to −0.16)
Psychoeducational interventionsSLE; not significant
−0.19(−0.46 to 0.09)
Follow-up models in consultationsRA; not significant
−0.05(−0.29 to 0.20)
Multicomponent interventionsRA; not significant
−0.20(−0.53 to 0.14)
Further pooled results
Other non-pharmacological interventions (RCTs not in meta-analysis)
- May provide a reduction of fatigue
Original publication
Efficacy of non-pharmacological interventions: a systematic review informing the 2023 EULAR recommendations for the management of fatigue in people with inflammatory rheumatic and musculoskeletal diseases. RMD Open. Published 21 August 2023. doi:10.
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