Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study
Authors' conclusion
The TaCCi mixture had similar efficacy and safety on urine alkalization and sUA-lowering as the citrate mixture and sodium bicarbonate in patients with gout. However, the TaCCi mixture resulted in greater improvements in UACR and CRP
Study context
- Population
- Men with gout and fasting urine pH ≤ 6 initiating urate-lowering therapy (ULT) with febuxostat (initially 20 mg daily, escalating to 40 mg daily if serum urate (sUA) ≥ 360 μmol/L)men with gout
- Participants
- 282 men
- Comparison
- TaCCi mixture vs citrate mixture vs sodium bicarbonate in men with gout initiating ULT with febuxostat
- Primary endpoint
- Co-primary: urine pH and sUA
Methodological detailsopen-label, parallel-controlled, prospective, Follow-up every 4 weeks until week 12
- Open-label
- Parallel-controlled
- Prospective
- Follow-up every 4 weeks until week 12
Primary result
As reported in the abstract
- Urine pH increased to a similar extent in all three groups
- sUA declined in all three groups, with no significant differences between groups
Secondary outcomes
| Outcome | P value |
|---|---|
| Reduction in UACR · week 12TaCCi mixture vs Citrate mixture and Sodium bicarbonate · greater reduction with TaCCi mixture | P < 0.05 |
| Gout flares over the study periodTaCCi mixture or Citrate mixture vs Sodium bicarbonate · fewer gout flares | P < 0.05 |
| CRP level · week 12TaCCi mixture vs Citrate mixture and Sodium bicarbonate · lower CRP with TaCCi mixture | P < 0.01 |
Safety
Adverse events
- Similar across all three groups
Original publication
Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study. Arthritis Res Ther. Published 7 September 2023. doi:10.
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