Effectiveness of longstanding exercise therapy compared with usual care for people with rheumatoid arthritis and severe functional limitations: a randomised controlled trial
Primary result · Change in PSC1 (0-10)Result — go to the resultMean difference −1.7 95% CI −2.4 to −1.0Authors' conclusion
Longstanding, supervised exercise therapy was more effective than usual care in people with RA and severe functional limitations.
Study context
- Population
- Adults with rheumatoid arthritis (RA) and severe functional limitations104 vs 98 available for analyses
- Participants
- 217 adults
- Comparison
- Longstanding supervised exercise therapy vs usual care
- Interventionn = 104
- Usual caren = 98reference
- Primary endpoint
- Change in Patient-Specific Complaints activity ranked 1 (PSC1, 0-10)
- Follow-up
- 52 weeks
Methodological details1:1 randomisation, blinded assessors
- 1:1 randomisation
- Blinded assessors
Primary result
Change in PSC1 (0-10)
Mean difference
−1.7
95% CI −2.4 to −1.0
Interventionvs Usual care
mean difference −1.7 (95% CI −2.4 to −1.0)
As reported in the abstract
Secondary outcomes
| Outcome | Estimate |
|---|---|
| Secondary outcomes at 52 weeks (difference)Intervention vs Usual care | PSC2 −1.8 (CI −2.4 to −1.1) |
| Secondary outcomes at 52 weeks (difference)Intervention vs Usual care | PROMIS PF-10 +3.09 (CI 1.80–4.38) |
| Secondary outcomes at 52 weeks (difference)Intervention vs Usual care | HAQ-DI −0.17 (CI −0.29 to −0.06) |
| Secondary outcomes at 52 weeks (difference)Intervention vs Usual care | RAQoL −2.03 (CI −3.39 to −0.69) |
| Secondary outcomes at 52 weeks (difference)Intervention vs Usual care | SF-36 PCS +3.83 (CI 1.49–6.17) |
| Secondary outcomes at 52 weeks (difference)Intervention vs Usual care | 6MWT +56 m (CI 38–75) |
- Secondary outcomes at 52 weeks (difference): all significantly greater improvements favouring the intervention except SF-36 MCS
Secondary outcomes at 52 weeks (difference)
- SF-36 MCS: no significantly greater improvement
Safety
- Adverse events (AEs) · mild, transient — Intervention
- 1 events
Original publication
Effectiveness of longstanding exercise therapy compared with usual care for people with rheumatoid arthritis and severe functional limitations: a randomised controlled trial. Ann Rheum Dis. Published 12 March 2024. doi:10.
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