Diseases associated with anti-centromere protein F (anti-CENP-F) antibodies: Insights from a large cohort study
Authors' conclusion
This study provides comprehensive insights into the clinical significance of anti-CENP-F antibodies.
Study context
- Population
- Anti-CENP-F positive patients identified among ≈151,000 antinuclear antibodies (ANA) screening samples over 12 years
- Participants
- 110 patients
- Outcome
- Associated diagnoses in anti-CENP-F positive patients
- Follow-up
- Median 3.8 years
Methodological detailsmultivariate analysis
- Multivariate analysis
Main finding
As reported in the abstract
Associated diagnoses
- Autoimmune diseases (most common)
- 38.2%
- Neurological diseases
- 15.5%
- Hemopathies
- 8.3%
- Cancer
- 10.9%
- Patients diagnosed with cancer, primarily lung and breast
- 12
Observational data: associations, not effects.
Further findings
Factors associated with cancer diagnosis (multivariate analysis)
- Older age and higher anti-CENP-F titers associated with cancer diagnosis
Patient characteristics
- Median age, years
- 50.9
- Women
- 73.6%
- Median CENP-F antibody titer
- 1:160
- Titer higher than 1:1280
- 16.4%
- Concomitant specific autoimmune antibody
- 29 (26.4%)
Original publication
Diseases associated with anti-centromere protein F (anti-CENP-F) antibodies: Insights from a large cohort study. Joint Bone Spine. Published 14 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →