Spondyloarthritis & psoriatic arthritis
Disease burden measured by patient-reported outcomes: does psoriatic arthritis feel worse than rheumatoid arthritis? A cross-sectional nationwide study
Authors' conclusion
Overall, both PsA and RA groups showed moderate disease control by patients' perspective, but the burden of disease was higher especially in women with PsA compared to RA. Disease activity was similar and low in both diseases.
Study context
- Population
- Patients with PsA and rheumatoid arthritis (RA) from a nationwide database; most recent visit/remote contact 1.2020 to 9.2021
- Participants
- 3,598 vs 13,913
- Exposure
- PsA vs RA
- PsAn = 3,598
- RAn = 13,913reference
- Outcome
- PROs: VAS pain, fatigue and PGA, and HAQ
Methodological detailsnationwide, regression analyses
- Nationwide
- Regression analyses
Main finding
As reported in the abstract
Patient-reported outcomes, overall
- Pain (VAS), median (IQR): PsA 29 (10, 56) vs RA 26 (10, 51)
- p<0.001
- Fatigue (VAS), median (IQR): PsA 29 (9, 60) vs RA 28 (8, 54)
- p<0.001
- Patient global assessment (PGA) (VAS), median (IQR): PsA 28 (10, 52) vs RA 29 (11, 51)
- p<0.001
- HAQ, median (IQR): PsA 0.4 (0, 0.9) vs RA 0.5 (0, 1.0)
- p<0.001
Observational data: associations, not effects.
Further findings
Patient-reported outcomes (PROs) by sex and age group
- Median pain, fatigue, PGA and HAQ higher for PsA vs RA in most age groups for males and females
- All PROs higher in older patients with both diagnoses
Disease activity, median (PsA vs RA)
- DAS28: 1.9 vs 2.0
- Doctor global assessment: 8 vs 8
- ESR: 7 vs 8
- CRP: 2 vs 3
Original publication
Disease burden measured by patient-reported outcomes: does psoriatic arthritis feel worse than rheumatoid arthritis? A cross-sectional nationwide study. Clin Exp Rheumatol. Published 13 November 2022. doi:10.
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