Dimerization as a key feature of autoreactive immunoglobulin A (IgA) antibody responses
Authors' conclusion
These findings indicate that dimeric (autoreactive) IgA responses are associated with newly emerging antigen-specific immune activation, where production temporarily shifts to dimeric IgA. Mucosal triggering is not necessarily always involved in these IgA immune responses.
Study context
- Population
- Plasma of patients with RA, SSc, AAV, SLE, SARS-CoV-2 vaccinated healthy individuals and healthy controls
- Comparison
- Dimeric proportion of autoreactive IgA vs total IgA in rheumatic autoimmune diseases, and of anti-spike IgA after SARS-CoV-2 vaccination
- Outcome
- Proportion of dimeric IgA, autoantibodies vs total IgA
Methodological detailssize exclusion chromatography, ELISA on size exclusion chromatography (SEC) fractions, confirmed by western blot and tandem mass spectrometry
- Size exclusion chromatography
- ELISA on SEC fractions
- Confirmed by western blot and tandem mass spectrometry
Main finding
As reported in the abstract
RA, AAV and SLE: dimeric autoreactive IgA vs total IgA
≈ 60%-80% vs total IgA ≈ 20%
SLE total IgA dimeric
≈ 60%
Original publication
Dimerization as a key feature of autoreactive IgA antibody responses. Ann Rheum Dis. Published 29 November 2025. doi:10.
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