Lupus & antiphospholipid syndrome
Differential glomerular expression patterns of Th17-related cytokines in Mexican patients with lupus nephritis
Authors' conclusion
These findings provide evidence for the compartment-specific expression in LN of Th17-related cytokines and IL-35 in Mexican patients.
Study context
- Population
- Mexican patients with moderate to severe lupus nephritis (LN)
- Participants
- 20 patients
- Outcome
- In-situ expression of IL-17A, IL-21, IL-22 and IL-35 in LN renal biopsies
Methodological detailsimmunohistochemistry in renal biopsy
- Immunohistochemistry in renal biopsy
Main finding
As reported in the abstract
In-situ cytokine expression by renal compartment
- Predominant expression of IL-17A and IL-21 in the glomerular region
- IL-22 detected in the tubulointerstitium and inflammatory aggregates
- IL-21 and IL-35 in fibrotic and atrophic tubules
- Positive correlation of glomerular and tubulointerstitial IL-17A expression with creatinine, urea and blood urea nitrogen levels
- IL-35 expression decreases in the presence of proteinuria
- IL-21 high in disease activity and severity; IL-35 decreased with systemic lupus erythematosus (SLE) disease activity
Observational data: associations, not effects.
Original publication
Differential glomerular expression patterns of Th17-related cytokines in Mexican patients with lupus nephritis. Lupus. Published 27 November 2025. doi:10.
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