Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and haemophagocytic lymphohistiocytosis (HLH) Across Speciality Collaboration (Hyperinflammation and HLH Across Speciality Collaboration (HiHASC)) consensus guideline

Lancet RheumatolPublished Consensus guideline

Methodological detailsliterature review and clinical experience, multidisciplinary working group
  • Literature review and clinical experience
  • Multidisciplinary working group

Recommendations

As issued by the authors

  1. Consider HLH in any acutely unwell patient not responding to treatment as expected, with prompt assessment for the three Fs: fever, falling blood counts and raised ferritin

  2. Prioritise inexpensive, readily available tests; the role of specialist investigations and their interpretation is also addressed

Original publication

Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline. Lancet Rheumatol. Published 29 November 2023. doi:10.1016/s2665-9913(23)00273-4

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