Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and haemophagocytic lymphohistiocytosis (HLH) Across Speciality Collaboration (Hyperinflammation and HLH Across Speciality Collaboration (HiHASC)) consensus guideline
Methodological detailsliterature review and clinical experience, multidisciplinary working group
- Literature review and clinical experience
- Multidisciplinary working group
Recommendations
As issued by the authors
Consider HLH in any acutely unwell patient not responding to treatment as expected, with prompt assessment for the three Fs: fever, falling blood counts and raised ferritin
Prioritise inexpensive, readily available tests; the role of specialist investigations and their interpretation is also addressed
Original publication
Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline. Lancet Rheumatol. Published 29 November 2023. doi:10. 1016/ s2665-9913(23)00273-4
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