Continuous decline in Paget’s disease of bone: a One Health perspective on 2342 new diagnoses and their association with rural livestock
Authors' conclusion
Our findings corroborate the ongoing reduction in the prevalence of PDB. This decline cannot be attributed solely to genetic factors and is likely a consequence of shifts in environmental influences.
Study context
- Population
- Clinically diagnosed Paget's disease of bone in Castille and Leon, central plateau of Spain, 2009–2019
- Participants
- 2,342 new Paget's disease of bone (PDB) cases
- Outcome
- Incidence of clinically diagnosed PDB and its association with livestock density
Methodological detailsprimary care electronic medical records, ecological analysis
- Primary care electronic medical records
- Ecological analysis
Main finding
As reported in the abstract
Correlation between PDB incidence and density of female breeding cattle (moderately positive), R2
0.236
Observational data: associations, not effects.
Original publication
Continuous decline in Paget’s disease of bone: a One Health perspective on 2342 new diagnoses and their association with rural livestock. Rheumatology (Oxford). Published 23 May 2025. doi:10.
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