Systemic sclerosis & Raynaud's
Clinical features of patients with systemic sclerosis positive for anti-SS-A antibody: a cohort study of 156 patients
Main finding · ILDResult — go to the resultOdds ratio 2.67 95% CI 1.14–6.3Authors' conclusion
Anti-SSA positivity increases the risk of organ involvement, such as ILD, in patients with SSc. Additionally, the anti-SSA-positive SSc without SS population may have more severe skin fibrosis than others.
Study context
- Population
- Patients with systemic sclerosis (SSc) at Yokohama City University Hospital, 2018–2021 (median age 69.0 years)18 men · 138 women
- Participants
- 156 patients
- Exposure
- Anti-SSA-positive vs anti-SSA-negative SSc
- Outcome
- Association of anti-SSA with clinical features (interstitial lung disease (ILD), organ involvement)
Methodological detailschart review, single-centre, multivariable logistic regression
- Chart review
- Single-centre
- Multivariable logistic regression
Main finding
ILD
Odds ratio
2.67
95% CI 1.14–6.3
P = 0.024
Anti-SSA-positivevs Anti-SSA-negative
OR 2.67 (95% CI 1.14–6.3); P = 0.024
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| ILD, autoantibody single-positivevs double-positive | 12.1 (2.13–140.57) | P = 0.003 | |
| dcSSc in anti-SSA-positive SSc, withoutvs with SS | 6.45 (1.23–32.60) | P = 0.024 | |
| 0.050.21520Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical features of patients with systemic sclerosis positive for anti-SS-A antibody: a cohort study of 156 patients. Arthritis Res Ther. Published 3 May 2024. doi:10.
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