Spondyloarthritis & psoriatic arthritis
Clinical and ultrasound features of a cohort of psoriasis patients without musculoskeletal symptoms: a prospective and multicentre study
Authors' conclusion
In a cohort of patients with mild PsO, systemic therapy-naive and no MSK symptoms, incidence of PsA was 1% per year. US bursitis at enthesis was related to the development of symptoms suggestive of PsA. Patients who developed MSK symptoms had higher BMI, fatigue and pain VAS scores at baseline and could constitute a subgroup with higher risk for transition to PsA.
Study context
- Population
- Psoriasis (PsO) patients without musculoskeletal (MSK) symptoms and no systemic treatment, followed by dermatologists60 completed
- Participants
- 78 patients
- Outcome
- Clinical and US features related to PsA development
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Development of MSK symptoms · median of 76.60 months (IQR 39.34-85.25)
- Developed MSK symptoms
- 34 patients (56.6%)
- Developed MSK inflammatory symptoms
- Five patients (8.3%)
- Met CASPAR criteria
- four (5.5%)
- Mean time from baseline to psoriatic arthritis (PsA) diagnosis, months
- 20.20 (SD ± 12.02)
- Those developing MSK symptoms: higher BMI
- P = 0.013
- Those developing MSK symptoms: higher abdominal circumference
- P = 0.022
- Those developing MSK symptoms: higher pain score
- P = 0.047
- Those developing MSK symptoms: higher fatigue score
- P = 0.011
- Those developing MSK symptoms: higher baseline total ultrasound (US) score
- P = 0.037
- US bursitis in patients developing inflammatory symptoms
- 80% (P = 0.049)
Observational data: associations, not effects.
Further findings
Baseline features
- Mean disease duration, years
- 15.1 (SD ± 13.4)
- Mild PsO
- 82%
- Onychopathy
- 36 (39.7%)
- Overweight/obesity
- 38 patients (48.7%)
- Power Doppler grade 1 at joints (US)
- nine patients (11.5%)
- Calcifications at enthesis (US)
- 56.4%
- Bursitis at enthesis (US)
- 30.4%
Original publication
Clinical and ultrasound features of a cohort of psoriasis patients without musculoskeletal symptoms: a prospective and multicentre study. Rheumatology (Oxford). Published 4 June 2025. doi:10.
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