Chasing the target: reports from the Advances in Targeted Therapies meeting, 2024
Authors' conclusion
There remain many unmet needs on the road to precision medicine with regard to identifying disease endotypes and biomarkers for disease progression or therapeutic response.
Study context
- Population
- More than 100 international clinicians and scientific researchers in rheumatology, immunology and other specialities relating to IMIDsmore than 100 experts
- Outcome
- Top unmet scientific needs for the next 5 years
Methodological detailsexpert discussion groups, 5 disease-specific discussion sections (rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (axSpA), osteoarthritis (OA), systemic lupus erythematosus (SLE)); experts identified the top 2 to 3 unmet needs
- Expert discussion groups
- 5 disease-specific discussion sections (RA, PsA, axSpA, OA, SLE); experts identified the top 2 to 3 unmet needs
Main finding
As reported in the abstract
- Overarching themes: precision medicine, improved classification of disease states, identification of targets and therapies, incl. potential role of chimeric antigen receptor (CAR) T cell therapies
- RA: lack of precision medicine, need for better biomarkers; lack of targeted therapies against fibroblasts
- PsA: better definition of disease endotypes and categorisation of complex and difficult-to-treat (D2T) disease; bispecific molecules and combination approaches a high priority
- axSpA: disease-modifying characteristics of NSAIDs need further evaluation, as does treatment of residual pain and fatigue
- OA: new therapeutic targets remain an unmet need; elucidating signalling and target cells for repair essential
- SLE: identify most predictive biological contributions to progression in early clinical precursors; further investigate CAR T cell therapy; relate patient-relevant symptoms to pathophysiology and identify new targets
Original publication
Chasing the target: reports from the Advances in Targeted Therapies meeting, 2024. Ann Rheum Dis. Published 15 April 2025. doi:10.
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