Cardiovascular risk assessment using the DAS28-GGT score in rheumatoid arthritis patients initiating JAK inhibitors: Results from the MAJIK-SFR registry

Perrot, L; Avouac, J; Truchetet, ME; Prati, C; Salmon, JH; Flipo, RM; Roux, C; Basch, A; Dernis, E; Salliot, C; Coury, F; Immediato Daien, C; Goupille, P; Thomas, T; Banneville, B; Martin, C; Ruyssen-Witrand, A; Giorgi, R; Pham, T

doi:10.1016/j.jbspin.2026.106113

Rheumatoid arthritis

Cardiovascular risk assessment using the DAS28-GGT score in rheumatoid arthritis patients initiating JAK inhibitors: Results from the MAJIK-SFR registry

Joint Bone SpinePublished 20 Jul 2026Cross-sectional study

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Authors' conclusion

This study supports the DAS28-GGT as a simple and practical tool to capture both cardiovascular risk and inflammatory activity in RA patients initiating JAKi.

Study context

Population: Rheumatoid arthritis (RA) patients initiating a Janus kinase inhibitors (JAKi) with available gamma-glutamyl transferase (GGT), MAJIK-SFR registry72% women
Participants: 185 patients

Exposure: DAS28-GGT vs DAS28-CRP for discriminating cardiovascular (CV) risk
Outcome: Discrimination of at least moderate CV risk (SCORE2 and Framingham) by AUC

Methodological detailsobservational registry, ROC curves, DeLong test

Observational registry
ROC curves
DeLong test

Main finding

As reported in the abstract

Discrimination of at least moderate CV risk

Group	SCORE2 AUC	Framingham AUC
DAS28-GGT	0.59	0.63
DAS28-CRP	0.52	0.53

SCORE2 AUC

DAS28-GGT0.59

DAS28-CRP0.52

Framingham AUC

DAS28-GGT0.63

DAS28-CRP0.53

DAS28-GGT vs DAS28-CRP: P < 0.05
DAS28-GGT vs DAS28-CRP: P < 0.01

Observational data: associations, not effects.

Further findings

Outcome	DAS28-GGT	DAS28-CRP
Baseline disease activity scoresMean	8.88 (SD 1.83)	4.07 (SD 1.27)
DAS28-GGT discrimination of DAS28-CRP disease activity categories
AUC remission	0.91	— not stated in the abstract
AUC low disease activity	0.70	— not stated in the abstract
AUC high disease activity	0.83	— not stated in the abstract

— not stated in the abstract

CV risk category distribution

SCORE2 low / moderate / high CV risk: 54.3% / 38.9% / 6.8%
Framingham low / moderate / high CV risk: 34.8% / 44.7% / 20.5%

Original publication

Cardiovascular risk assessment using the DAS28-GGT score in rheumatoid arthritis patients initiating JAK inhibitors: Results from the MAJIK-SFR registry. Joint Bone Spine. Published 20 July 2026. doi:10.1016/j.jbspin.2026.106113

Read the original article ↗

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