Spondyloarthritis & psoriatic arthritis
Bimekizumab provided rapid improvements in patient-reported symptoms and health-related quality of life in patients with active psoriatic arthritis: pooled 16-week results from two phase 3 studies
Authors' conclusion
Bimekizumab treatment demonstrated rapid and greater improvements in patient-reported pain, fatigue, physical function and HRQoL to week 16 vs placebo in bDMARD-naïve and TNFi-IR patients.
Study context
- Population
- Patients with active psoriatic arthritis (PsA), biologic disease-modifying antirheumatic drug (bDMARD)-naïve (BE OPTIMAL) or TNFi inadequate response/intolerance (BE COMPLETE)1,073 completed week 16
- Participants
- 1,112 patients
- Comparison
- Subcutaneous bimekizumab 160 mg Q4W vs placebo
- Bimekizumabn = 698
- Placebon = 414reference
- Outcome
- Pain Visual Analogue Scale (VAS), mean change from baseline
- Follow-up
- Week 16
Methodological detailsBE OPTIMAL and BE COMPLETE, double-blind, placebo-controlled to 16 weeks, pooled and individual study data
- BE OPTIMAL and BE COMPLETE
- Double-blind
- Placebo-controlled to 16 weeks
- Pooled and individual study data
Pooled result
As reported in the abstract
Bimekizumab
-25.2
mean · 95% CI −27.2–-23.1
Placebo
-5.7
mean · 95% CI −8.2–-3.3
Nominal p<0.001
Further pooled results
FACIT-Fatigue MCID achieved · week 16
nominal p<0.001
HAQ-DI MCID achieved · week 16
nominal p<0.001
Mean
| Outcome | Bimekizumab | Placebo | P value |
|---|---|---|---|
| FACIT-Fatigue, mean change from baseline · week 16 | 4.5 (95% CI 3.9–5.1) | 1.1 (95% CI 0.3–2.0) | nominal p<0.001 |
Pain, fatigue, physical function and health-related quality of life (HRQoL) after a single dose · week 4
- Rapid improvements with bimekizumab vs placebo
Original publication
Bimekizumab provided rapid improvements in patient-reported symptoms and health-related quality of life in patients with active psoriatic arthritis: pooled 16-week results from two phase 3 studies. RMD Open. Published 23 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →