Bidirectional association of rheumatoid arthritis and inflammatory bowel diseases: a large-scale prospective cohort study
Authors' conclusion
IBD is associated with an increased risk of RA, and vice versa.
Study context
- Population
- Participants free of any cancer at baseline, large-scale population-based cohortcohort 1: 449,662
- Exposure
- Inflammatory bowel disease (IBD) vs non-IBD; Rheumatoid arthritis (RA) vs non-RA
- IBDn = 5,015
- RAn = 5,887
- Outcome
- Incident RA in cohort 1; incident IBD, including ulcerative colitis (UC) and Crohn's disease (CD), in cohort 2
Methodological detailspopulation-based, bidirectional (two cohorts), Cox proportional hazard regression, multivariable adjustment
- Population-based
- Bidirectional (two cohorts)
- Cox proportional hazard regression
- Multivariable adjustment
Main finding
As reported in the abstract
Incident RA (cohort 1); incident IBD (cohort 2) · median 14.3- and 14.6-year follow-up
Hazard ratio (95% CI)
IBDvs Non-IBDincident RA; multivariable adjustment
1.44(1.15–1.79)
RAvs Non-RAincident IBD
1.65(1.31–2.09)
- Incident RA cases, cohort 1
- 6001 (1.3%)
- Incident IBD cases, cohort 2
- 2988 (0.7%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident RA in UC patients (subgroup)UCvs Non-IBD | 1.36 (1.06–1.75) | |
| Incident UC and CD in RARAvs Non-RAIncident UC | 1.60 (1.20–2.13) | |
| Incident UC and CD in RARAvs Non-RAIncident CD | 1.65 (1.12–2.42) | |
| 0.512Hazard ratio (log scale) |
Sensitivity and subgroup analyses
- Similar results
Original publication
Bidirectional association of rheumatoid arthritis and inflammatory bowel diseases: a large-scale prospective cohort study. Rheumatology (Oxford). Published 13 June 2025. doi:10.
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