Beyond uric acid: Allantoin reflects oxidative stress, disease burden, and cardiovascular comorbidities in hyperuricemia and gout
Authors' conclusion
Serum allantoin and the allantoin/UA ratio are elevated in hyperuricemia and gout, particularly in patients with tophaceous disease or concomitant arterial hypertension. After adjustment for renal function, age, and sex, allantoin remains independently associated with disease severity and cardiovascular comorbidity, supporting its role as a marker of oxidative stress burden.
Study context
- Population
- Patients with gout, individuals with asymptomatic hyperuricemia and healthy controls
- Participants
- 154 / 55 / 47
- Exposure
- Gout and asymptomatic hyperuricemia vs healthy controls
- Goutn = 154
- Asymptomatic hyperuricemian = 55
- Healthy controlsn = 47reference
- Outcome
- Serum allantoin levels and allantoin/UA ratio, with respect to disease severity and cardiovascular comorbidities
Methodological detailslogistic regression adjusted for eGFR, age, and sex, Allantoin quantified by fully validated UHPLC-MS/MS method
- Logistic regression adjusted for eGFR, age, and sex
- Allantoin quantified by fully validated UHPLC-MS/MS method
Main finding
As reported in the abstract
Serum allantoin and allantoin/UA ratio
- Significantly higher in patients vs controls
- No difference between gout and hyperuricemia
- Gout vs Healthy controls: P < 0.001
Observational data: associations, not effects.
Further findings
Correlations of allantoin
- Correlation with eGFR (r)
- r=−0.25, P<0.001
- Correlation with CRP (r)
- r=0.22, P=0.001
- Uric acid (UA) not an independent predictor in multivariable analysis
- P = 0.14
- eGFR and CRP remained independent predictors in multivariable analysis
Allantoin and clinical outcomes (adjusted logistic regression)
- Tophi, OR
- OR 2.34, P=0.050
- Arterial hypertension, OR
- OR 2.26, P=0.046
- Gout flares, OR (borderline)
- OR 2.52, P=0.053
- Adjusted for eGFR, age, and sex
- Estimates unchanged after additional adjustment for UA
Original publication
Beyond uric acid: Allantoin reflects oxidative stress, disease burden, and cardiovascular comorbidities in hyperuricemia and gout. Joint Bone Spine. Published 30 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →