Association of Serum Soluble Transferrin Receptor Concentration With Markers of Inflammation: Analysis of 1001 Patients From a Tertiary Rheumatology Center
Authors' conclusion
The study provides evidence against the concept that sTfR is a biomarker not affected by inflammation.
Study context
- Population
- Patients with known or suspected inflammatory rheumatic disease (IRD) referred to a tertiary rheumatology center
- Participants
- 1,001 patients
- Exposure
- Active IRD vs inactive or no IRD
- Outcome
- Relationship between serum sTfR levels and inflammatory markers (CRP, ESR)
Methodological detailssingle tertiary rheumatology center, correlation analyses, multiple linear regression
- Single tertiary rheumatology center
- Correlation analyses
- Multiple linear regression
Main finding
As reported in the abstract
Correlation of inflammatory markers with serum sTfR
CRP vs soluble transferrin receptor (sTfR), ρ (P < 0.001)
0.44
ESR vs sTfR, ρ (P < 0.001)
0.43
CRP vs ferritin, ρ (P < 0.001)
0.30
ESR vs ferritin, ρ (P < 0.001)
0.23
Observational data: associations, not effects.
Further findings
Serum sTfR by IRD activity
P < 0.001
CRP as predictor of serum sTfR (multiple linear regression, adjusted)
- CRP levels predictive for serum sTfR after adjustment (P < 0.001)
Original publication
Association of Serum Soluble Transferrin Receptor Concentration With Markers of Inflammation: Analysis of 1001 Patients From a Tertiary Rheumatology Center. J Rheumatol. Published 15 January 2024. doi:10.
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