Spondyloarthritis & psoriatic arthritis
Association of circulating lymphocyte subsets with response to IL17i and TNFi in axial spondyloarthritis
Authors' conclusion
This pilot work demonstrated a dysregulation of LS in axSpA. The association observed between several LS and clinical response to IL17i (NK/CD8 subsets/Th17-KIR3DL2) was very different to that observed for TNFi (CD4/IL-6R).
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) and control subjects
- Participants
- 69 / 141 / 36 / 26
- Exposure
- axSpA vs HC; responders vs non-responders to IL17i or TNFi
- axSpAn = 69
- HCn = 141reference
- TNFin = 36
- IL17in = 26
- Outcome
- Circulating lymphocyte subset abnormalities in axSpA and their association with clinical response to biologic disease-modifying anti-rheumatic drugs (b-DMARDs) (50% reduction of BASDAI or decrease in ASDAS of 1.1 point)
- Follow-up
- 6 months
Methodological detailsflow cytometry, prospective follow-up at 6 months in a subgroup
- Flow cytometry
- Prospective follow-up at 6 months in a subgroup
Main finding
As reported in the abstract
Circulating lymphocyte subsets, axSpA vs HC · baseline
- axSpA vs HC: P < 0.003 after correction
Observational data: associations, not effects.
Further findings
Response to IL17i, association with lymphocyte subsets · 6 months
- Response rate to IL17i
- 61%
- Trends for change in naïve/memory-CD8+T-cells
- P < 0.055
- Increased expression of KIR3DL2 on Th17-cells
- P = 0.052
- Higher frequency of NK-cells associated with response (p=0.003)
Response to TNFi, association with lymphocyte subsets · 6 months
- Response rate to TNFi
- 69%
- No lymphocyte subsets (LS) associated with response to TNFi; trends observed (CD4+T-cell subsets, higher IL-6R on CD4+/CD8+T-cells)
Response to bDMARDs, association with clinical data
- No association of response to bDMARDs with clinical data
Original publication
Association of circulating lymphocyte subsets with response to IL17i and TNFi in axial spondyloarthritis. Clin Exp Rheumatol. Published 16 December 2021. doi:10.
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