Association between radiographic and functional outcome in vertebral osteomyelitis SPONDIMMO, a 6-month prospective multicenter cohort
Authors' conclusion
Our study demonstrates structural and static radiographic progression after 3 months. Only the complete fusion progressed over the long-term. Functional impairment was associated with persistence of vertebral destruction.
Study context
- Population
- Patients with vertebral osteomyelitis, 11 French centres, 2016–2019 (mean age 67.8±14 years; 67.6% men)
- Participants
- 222 patients
- Outcome
- Radiographic (structural and static criteria on X-ray) and functional (Oswestry Disability Index) evolution
- Follow-up
- 6 months
Methodological detailsmulticentre, 11 French centres
- Multicentre
- 11 French centres
Main finding
As reported in the abstract
Radiographic and functional evolution
- Vertebral fusion, baseline vs 3 months (significant increase)
- 16.4% vs 52.7%
- Destruction of vertebral bodies, baseline vs 3 months (significant increase)
- 10.1% vs 22.8%
- Frontal angulation, baseline vs 3 months (significant increase)
- 15.2% vs 24.4%
- Segmental kyphosis, baseline vs 3 months (significant increase)
- 34.6% vs 56%
- Regional kyphosis, baseline vs 3 months (significant increase)
- 24.5% vs 41%
- Complete fusion, 3 to 6 months (only X-ray abnormality progressing significantly)
- 16.6% vs 27.2%
- Median Oswestry Disability Index (ODI), 3 vs 6 months (significant improvement)
- 24, IQR [11.5-38] vs 16, IQR [6-34]
- Severe disability at 6 months
- 14.1%
- Major disability at 6 months
- 2%
Observational data: associations, not effects.
Further findings
ODI at 6 months by persistence of vertebral destruction (persistence associated with higher ODI)
- Median ODI, without vs with persistent vertebral destruction
- 16, IQR [7.5-30.5] vs 27, IQR [11.5-44.5]
Radiological progression with rigid brace immobilization
- No differences in radiological progression with rigid brace
Original publication
Association between radiographic and functional outcome in vertebral osteomyelitis SPONDIMMO, a 6-month prospective multicenter cohort. Joint Bone Spine. Published 16 June 2023. doi:10.
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